Association of breast implants with anaplastic large-cell lymphoma
Menée aux Pays-Bas à partir de données portant sur 43 patientes atteintes d'un lymphome anaplasique à grandes cellules dans le sein (âge médian : 59 ans) diagnostiqué entre 1990 et 2016, cette étude évalue l'association entre des implants mammaires et le risque de développer la maladie
The case-control study by Dr de Boer and colleagues2 published in this issue of JAMA Oncology serves to further refine our understanding of the risk of BIA-ALCL. Using a comprehensive Dutch pathology database, the authors calculated the risk of breast-ALCL in women both with and without breast implants. Their findings suggest that the absolute risk of breast-ALCL is 1 in 35 000 at age 50 years, 1 in 12 000 at 70 years, and 1 in 7000 at 75 years in women with breast implants. Although this seems to suggest that the risk of disease increases with increasing age, it remains unclear if chronologic age alone is an independent risk factor for the disease. It has been hypothesized that the absolute risk of BIA-ALCL has less to do with age per se, but rather with the duration of implant exposure over time.3 In the current series, the median time to development of BIA-ALCL was 13 years after an implant was placed.