New directions in penile cancer
A partir d'une revue systématique de la littérature publiée entre 1986 et 2017 (73 articles), cette méta-analyse évalue, au niveau mondial, la présence d'une infection par le papillomavirus humain et d'une surexpression de la protéine p16 INK4a dans les cancers du pénis et dans les néoplasies intraépithéliales du pénis
Penile cancer is a rare disease, but offers insight into aspects of viral carcinogenesis and potential for personalised radiotherapy. The study by Tina Olesen and colleagues in The Lancet Oncology is a well performed viral epidemiology analysis by an accomplished Danish team. The investigators screened the published literature for cases of penile cancer and penile intraepithelial neoplasia and collated their findings with reports of human papillomavirus (HPV) DNA and p16 INK4a positivity. The authors report a pooled HPV prevalence of 50·8% in penile cancer (which was especially high in basaloid squamous cell carcinomas and warty-basaloid carcinoma), with HPV16 being the predominant oncogenic HPV type, and a pooled HPV prevalence in penile intraepithelial neoplasia of 79·8%. The pooled p16 INK4a percent positivity was 41·6% in penile cancer and 49·5% in penile intraepithelial neoplasia