Normal weight adiposity and postmenopausal breast cancer risk
Menée aux Etats-Unis à partir de données portant sur 3 460 participantes âgées de 50 à 79 ans et présentant un indice de masse corporelle normal (de 18,5 à 24,9), cette étude évalue l'association entre l'adiposité, mesurée par absorptiométrie bi-énergétique par rayons X, et le risque de cancer du sein, et notamment un cancer du sein ER+ (durée médiane de suivi : 16 ans ; 182 cas)
Adipose tissue is recognized as an active metabolic organ, with excess adiposity associated with endocrine and metabolic attributes, including insulin resistance, altered adipokines (higher leptin and lower adiponectin levels), inflammation, and higher estrogen levels. Many of these factors, in addition to obesity, which is defined as a BMI (body mass index, calculated as weight in kilograms divided by height in meters squared) of 30 or higher, have been linked to an increased risk of breast cancer, notably in postmenopausal women.1,2
JAMA Oncology 2018