Beyond Epstein-Barr virus: genetic predisposition of natural killer T-cell lymphoma
Menée en Chine à partir de données portant sur 189 patients atteints d'un lymphome T ou NK extraganglionnaire de type nasal et sur 957 témoins, puis validée sur 4 études cas-témoins indépendantes (325 cas et 4 865 témoins au total), cette étude d'association sur le génome entier identifie des polymorphismes du gène HLA-DPB1 prédisposant au risque de la maladie
Genome-wide association studies (GWASs) help to identify the genetic predisposition of various diseases, including malignancies. This data-driven approach is useful for identifying individuals at high risk of developing certain cancers and mechanisms of carcinogenesis that might lead to discovery of new targets for treatment.1 Extranodal natural killer T-cell lymphoma (NKTCL), nasal type, is a rare, aggressive malignancy and is particularly prevalent in Asian and Latin American populations. Most NKTCL cases are characterised by the presence of CD56, cytoplasmic CD
ε, and cytotoxic molecules, and by the expression of perforin, granzyme B, T cell-restricted intracellular antigen (TIA1), and Epstein-Barr virus (EBV)-encoded RNA (which can be detected by in-situ hybridisation).