Leaky transporters and sphincters in Barrett's oesophagus?
A partir des données d'études d'association sur le génome entier publiées jusqu'en 2016 et incluant 6 167 patients atteints d'un endobrachyœsophage, 4 112 patients atteints d'un adénocarcinome œsophagien et 17 159 témoins, cette méta-analyse identifie de nouveaux variants de susceptibilité génétique impliqués dans le développement de ces maladies
Barrett's oesophagus is a metaplastic epithelial condition caused by chronic gastro-oesophageal reflux that predisposes to development of oesophageal adenocarcinoma. Barrett's oesophagus and oesophageal adenocarcinoma are not often thought of as hereditary diseases—ie, a positive family history of either disease in first-degree relatives or probands is usually not obtained.1 However, since these diseases could be polygenic in origin, with each locus contributing only weakly to disease development, clinical family history might underestimate the hereditary genetic component.
The Lancet Oncology 2016