Negative studies in cancer research: Why the negativity?
A partir d'une analyse de 94 essais de phase III menés par le consortium américain SWOG entre 1985 et 2014 (46 424 patients inclus au total), cette étude évalue, à l'aide des facteurs d'impact des revues dans lesquelles les résultats sont publiés, l'impact scientifique des essais selon que leurs résultats sont positifs ou négatifs
Shortly after the US Congress appropriated $5 million to establish the National Cancer Institute (NCI) in 1955, cooperative groups were organized to accelerate the fight against cancer. Their coordinated efforts have been very successful, generating evidence that has influenced the entire spectrum of cancer care. Yet NCI cooperative groups face significant challenges in the current austere research funding environment. With limited funds, assessing the scientific impact of previously funded research offers the potential to guide optimal and efficient use of scarce research dollars.
JAMA Oncology 2016