TGF-β/SMAD/GLI2 Signaling Axis in Cancer Progression and Metastasis
Cet article passe en revue les travaux récents sur la fonction du facteur de transcription GLI2 dans la voie de signalisation TGF-β au cours de la progression d'un cancer et du processus métastatique
The Hedgehog (HH) and TGF-β signaling pathways represent essential regulators of cell proliferation and differentiation during embryogenesis. Pathway deregulation is a characteristic of various cancers. Recently, evidence for a convergence of these pathways at the level of the GLI2 transcription factor in the context of tumor initiation and progression to metastasis has emerged. This short review summarizes recent knowledge about GLI2 function and mechanisms of action downstream of TGF-β in cancer. Cancer Res; 71(17); 1–5. ©2011 AACR.