Understanding the Enemy
Cette étude montre que la fusion des gènes WWTR1 et CAMTA1 est caractéristique d'un hémangioendothéliome épithélioïde, un sarcome vasculaire rare
In this issue of Science Translational Medicine, Tanas and colleagues describe a disease-defining genetic alteration for the vascular cancer epithelioid hemangioendothelioma (EHE). The resulting EHE-associated fusion gene encodes an aberrantly expressed putative transcription factor. This molecular information is the latest in a series of genetic discoveries that aid in cancer diagnosis and may pave the way to targeted therapeutic agents.
Science Translational Medicine , commentaire, 2011