DNA repair: From genome maintenance to biomarker and therapeutic target
Cet article passe en revue les travaux récents sur l'intérêt de biomarqueurs associés aux voies de réparation de l'ADN pour l'évaluation de la réponse thérapeutique
A critical link exists between an individual's ability to repair cellular DNA damage and cancer development, progression and response to therapy. Knowledge gained regarding the proteins involved and types of damage repaired by the individual DNA repair pathways has led to the development of a variety of assays aimed at determining an individual's DNA repair capacity. These assays and their use in the analysis of clinical samples has yielded useful though somewhat conflicting data. In this review article, we discuss the major DNA repair pathways, the proteins and genes required for each, assays used to assess activity and the relevant clinical studies to date. With the recent results from clinical trials targeting specific DNA repair proteins for the treatment of cancer, accurate, reproducible and relevant analysis of DNA repair takes on an even greater significance. We highlight the strengths and limitations of these DNA repair studies and assays with respect to the clinical assessment of DNA repair capacity to determine cancer development and response to therapy.
Clinical Cancer Research , résumé, 2011