When is a little breast tissue too much ? Nipple-sparing risk-reducing mastectomy in brca carriers
Menée à partir de données portant sur 346 patientes présentant une mutation BRCA1 ou BRCA2 et atteintes ou non d'un cancer du sein (âge médian : 41 ans ; durée médiane de suivi : 34 mois), cette étude multicentrique évalue la sécurité d'une mastectomie prophylactique épargnant le mamelon ainsi que son efficacité pour réduire soit le risque de cancer du sein, soit le risque de récidive ipsilatérale ou controlatérale
Whether a proportional reduction in the volume of breast tissue proportionately reduces the risk of developing breast cancer has been seriously debated in light of the recognition that most patients undergoing prophylactic mastectomy have residual breast tissue, including terminal ductal units in the skin flaps.1,2 Animal studies3 from 1986 suggested that the risk of developing mammary tumors was not proportionately reduced by the amount of breast tissue removed. Thus, it was recommended that if absolute protection was desired, a total mastectomy, including the nipple-areolar complex, was required.3