Hidden Immunotherapy Targets Challenge Dogma
Menée sur des modèles murins, cette étude évalue l'efficacité antitumorale d'une immunothérapie à base d'anticorps monoclonaux dirigés contre des protéines intracellulaires
In this issue of Science Translational Medicine, Guo et al. discuss the intriguing possibility that intracellular tumor antigen–specific monoclonal antibodies (mAbs) inhibit tumor growth and metastasis and prolong survival of tumor-bearing mice. Here, I discuss the implications of using intracellular targets in mAb-based immunotherapy as well as the possible underlying mechanisms of action.
Science Translational Medicine , commentaire, 2011