Breast Cancer Susceptibility Polymorphisms and Endometrial Cancer Risk: a Collaborative Endometrial Cancer Study
Menée sur 4 188 cas de cancer de l'endomètre et 11 928 témoins, cette étude évalue l'assocation entre neuf polymorphismes à simple nucléotide, précédemment associés à un risque de cancer du sein, et un risque de cancer de l'endomètre
Recent large-scale association studies, both of genome wide and candidate gene design, have revealed several single nucleotide polymorphisms (SNPs) which are significantly associated with risk of developing breast cancer. As both breast and endometrial cancers are considered to be hormonally driven and share multiple risk factors, we investigated whether breast cancer risk alleles are also associated with endometrial cancer risk. We genotyped nine breast cancer risk SNPs in up to 4,188 endometrial cases and 11,928 controls, from between three and seven Caucasian populations. None of the tested SNPs showed significant evidence of association with risk of endometrial cancer.
http://carcin.oxfordjournals.org/content/early/2011/09/28/carcin.bgr214.abstract