Growing Evidence for the Role of Air Pollution in Breast Cancer Development
Menée à partir de données portant sur 58 358 Américaines (durée moyenne de suivi : 19,3 ans), cette étude analyse l'association entre les polluants atmosphériques (PM2.5 en particulier) et le risque de cancer du sein (3 524 cas)
Breast cancer remains the most commonly diagnosed cancer among women in the United States and worldwide. Although survival after a breast cancer diagnosis is high (91% at 5 years after diagnosis), there are wide-ranging consequences, including treatment side effects, adverse mental health impacts, and high financial toxicity. Epidemiologic research has identified a number of breast cancer risk factors, including reproductive history (eg, age at menarche, parity, breastfeeding) as well as alcohol use, postmenopausal obesity, and cigarette smoking. Despite the large number of identified risk factors and the proliferation of interventions to reduce some of these exposures, incidence rates have increased for many groups. The lack of progress may be attributed in part to the fact that most of these risk factors are not easily modifiable and only modestly contribute to incidence (ie, relative risk estimates <2.0).