Identifying Novel Genetic Markers Through Transcription-Wide Association Study: Can This Be A Path To Reducing The Burden of Pancreatic cancer?
A l'aide de données portant sur le génome entier de 9 040 patients atteints d'un cancer du pancréas et de 12 496 témoins, cette étude d'association à l'échelle du transcriptome identifie de nouveaux gènes de susceptibilité à la maladie
Pancreatic cancer is one of the most lethal malignancies worldwide, and rates of occurrence and mortality are similar; in 2018, an estimated 458,918 cases of pancreatic cancer occurred globally and 432,242 diedfrom the disease[1]. Ofthosediagnosed with pancreatic cancer, half will die within six months and the five year survival for pancreatic cancer isa dismal8%[2]. Another alarmingfact is thatincidence rates have increased by 1.5% per year since 2004 in the United States[3]. Several factors contribute tothis high fatality rate, including few known modifiable risk factors, no effective screening tools, and lack of early diagnostic symptoms unique to pancreaticcancer.The exact factors driving this increasing trend inincidence have yet to be elucidated.