Treatment-Associated Breast Cancer Following Childhood Cancer: Where Do We Go From Here?
Menée auprès de 11 550 femmes ayant survécu au moins 5 ans à un cancer pédiatrique traité sur la période 1970-1999 (âge médian : 34,2 ans), cette étude analyse l'association entre l'évolution temporelle des traitements par radiothérapie et l'incidence des cancers du sein
Improvements in cancer-directed therapy and supportive care have led to a large and growing population of childhood cancer survivors. However, many patients develop chronic and life-threatening health conditions associated with cancer treatment. Concerningly, and cruelly, in some cases the very treatment required to cure a child of cancer places them at risk for developing other cancers later in life. Unfortunately, cancer treatment-associated tumors are a leading cause of mortality among childhood cancer survivors, with invasive breast cancer being one of the most common subsequent malignant neoplasms diagnosed. As patients who had childhood cancer continue to have improved survival owing to advancement in initial cancer therapies, counseling on the risk of subsequent tumors is more important than ever.