Paramagnetic Localization—A Viable Option for Nonpalpable Breast Lesions
Mené sur 426 patientes atteintes d'un cancer du sein (âge médian : 65 ans), cet essai randomisé de phase III évalue l'équivalence, du point de vue du taux de nouvelle résection et du rapport volume réséqué/volume de résection optimal, de deux stratégies de marquage pré-opératoire de la tumeur et du ganglion sentinelle : l'une utilisant des grains ferromagnétiques et des nanoparticules d'oxyde de fer superparamagnétique (SPIO), l'autre utilisant un fil de guidage et des nanoparticules SPIO
Improvements in breast cancer screening have increased the diagnosis of nonpalpable breast cancers. As breast-conserving surgery has become the primary method of surgical management for these cancers, surgeons have become more reliant on accurate localization techniques to correctly identify nonpalpable breast lesions. Guidewire localization has been the primary method used since it was first described in 1965. Since then, several other localization techniques have been introduced and tested in clinical trials. Pantiora et al compared paramagnetic seeds vs guidewires for localization of nonpalpable breast cancers in a randomized clinical trial (RCT). Both arms in the trial used superparamagnetic iron oxide (SPIO) for sentinel lymph node localization. Although previous cohort studies have found comparable re-excision rates between paramagnetic seeds and guidewires, this is the first RCT, to our knowledge, to show equivalence between these 2 techniques.