RAS oncogenes: weaving a tumorigenic web
Cet article passe en revue les travaux récents sur les voies de signalisation impliquant les oncogènes RAS dans les processus cellulaires de la tumorigenèse
RAS proteins are essential components of signalling pathways that emanate from cell surface receptors. Oncogenic activation of these proteins owing to missense mutations is frequently detected in several types of cancer. A wealth of biochemical and genetic studies indicates that RAS proteins control a complex molecular circuitry that consists of a wide array of interconnecting pathways. In this Review, we describe how RAS oncogenes exploit their extensive signalling reach to affect multiple cellular processes that drive tumorigenesis.