Aspirin and chemoprevention—have we arrived?
Ce dossier présente deux études, l'une évaluant l'association entre l'utilisation d'analgésiques (aspirine ou autres anti-inflammatoires non stéroïdiens, paracétamol) et le risque de cancer de l'ovaire (1 054 cas de cancer de l'ovaire sur 205 498 participantes), l'autre évaluant l'association entre l'utilisation d'aspirine et le risque de carcinome hépatocellulaire (108 cas pour 133 371 participants dont 87 507 femmes ; durée de suivi : 4 232 188 personnes-années)
Aspirin (acetylsalicylic acid) is one of the oldest and most widely used medications worldwide. In 400 BC, Hippocrates described the ability of salicylic tea to relieve fever; by the 19th century, pharmacists were widely prescribing salicylic acid derivatives. Today in the United States alone, almost half of adults ages 45 to 75 years take aspirin on a regular basis.2 For those who take aspirin regularly, there is a widespread belief in aspirin’s anticancer potential; in a 2015 study2 (prior to any formal cancer prevention guidelines), 18% of Americans who took aspirin regularly said they were doing so to prevent cancer.
JAMA Oncology , éditorial en libre accès, 2017