Risk of Breast Cancer in Families with Cleft Lip and Palate
Cette étude danoise évalue le risque de cancer du sein chez des femmes issues de familles présentant des cas de fente labiale et de fente palatine
To test whether female subjects in families with cleft lip and/or palate (CL/P) have an increased risk of breast cancer. By using the Danish Facial Cleft Registry, we identified female subjects with CL/P, mothers of children with CL/P, and sisters to CL/P cases for the Danish birth cohorts 1911–1975. These subjects were compared with a 5% random sample of these cohorts regarding the incidence and age of onset for breast cancer registered in the Danish Hospital Discharge Register 1977–2005. Examining 48,404 person-years for 1809 female CL/P cases (49 breast cancer cases) and 212,795 person-years for 7935 female relatives (188 breast cancer cases), we found no increased breast cancer risk for either CL/P cases (hazard ratio [HR], 1.23; 95% confidence interval (CI), 0.92–1.63), mothers of children with CL/P (HR, 0.93; 95% CI, 0.80–1.08), or sisters of CL/P cases (HR, 0.94; 95% CI, 0.55–1.60), nor was there any significant differences in age of onset. Both epidemiological and genetic studies have suggested common etiological factors for breast cancer and CL/P. However, in this population-based study we were not able to confirm a general increase in the risk of breast cancer among female subjects in families with CL/P.