A New Lnc in Metastasis: Long Noncoding RNA Mediates the ProMetastatic Functions of TGF-β
Menée in vitro, in vivo et à partir d'échantillons tumoraux prélevés sur des patients chinois atteints d'un carcinome hépatocellulaire, cette étude identifie des mécanismes par lesquels un long ARN non codant, activé par la signalisation
TGF-
β
signaling promotes metastasis by controlling the expression of downstream target genes. In this issue of Cancer Cell, Yuan and colleagues discover a novel TGF-?-induced lncRNA, lncRNA-ATB, which stimulates EMT through sequestering miR-200s and facilitates colonization by stabilizing IL-11 mRNA, thus promoting both early and late steps of cancer metastasis.