Cancer-Associated Osteoclast Differentiation Takes a Good Look in the miR(NA)ror
Menée in vitro et in vivo, cette étude met notamment en évidence des mécanismes par lesquels deux micro-ARNs, miR-16 et miR-378, favorisent la formation de métastases osseuses d'un cancer du sein
Tumor-bone cell interactions are critical for the development of metastasis-related osteolytic bone destruction. In this issue of Cancer Cell, Ell and colleagues show how a discrete miRNA network regulates osteoclastogenesis during breast cancer bone metastasis. A signature of upregulated miRNAs may have diagnostic and therapeutic implications for bone metastases.