p62 in Liver Disease: Good Guy or Bad Guy?
Menée in vitro et in vivo, cette étude met en évidence des mécanismes par lesquels, en augmentant la fibrose et l'inflammation du foie, la perte d'expression du gène p62 favorise le développement d'un carcinome hépatocellaire
The multidomain adaptor protein p62 has been suggested to exert pro-oncogenic functions in hepatocytes and other epithelial cells. In this issue of Cancer Cell, Duran et al. show that p62 acts as a non-cell-autonomous tumor suppressor in liver cancer by counteracting the activation of hepatic stellate cells.