PIPPing on AKT1: How Many Phosphatases Does It Take to Turn off PI3K?
Menée in vivo, cette étude met en évidence des mécanismes par lesquels, en régulant la migration des cellules tumorales, la phosphatase PIPP réprime le processus métastatique d'un cancer du sein
In this issue of Cancer Cell, Ooms and colleagues show that the lipid phosphatase PIPP/INPP5J, frequently inactivated in triple-negative breast cancers, functions as a tumor suppressor by specifically modulating the activity of AKT1 in the context of oncogenic PI3K signaling, leading to inhibition of metastatic dissemination.