The Tropism of Pleiotrophin: Orchestrating Glioma Brain Invasion
Menée à l'aide de modèles murins de gliome, cette étude met en évidence des mécanismes par lesquels, en sécrétant un complexe contenant de la pléïotropine, des cellules souches neurales favorisent le processus invasif
The lateral ventricle (LV) is a preferential location for brain tumor spread; however, the instructive cues responsible for this unique tropism were previously unknown. In this issue, Qin et al. elucidate the underlying mechanism, demonstrating that LV-neural progenitors secrete a pleiotrophin (PTN)-containing complex, which attracts glioma cells through ROCK/Rho activation.