Platelets Alter Tumor Cell Attributes to Propel Metastasis: Programming in Transit
Menée in vitro et in vivo, cette étude identifie un mécanisme de signalisation entre cellules cancéreuses et thrombocytes induisant une transition épithélio-mésenchymateuse et favorisant le processus métastatique
Metastasis of epithelial tumors critically depends on acquisition of a disseminating phenotype that allows tumor cells to colonize distant organs. In this issue of Cancer Cell, Labelle et al. demonstrate that an epithelial-mesenchymal-like transition can be induced by interaction between platelets and tumor cells.
Cancer cell , commentaire, 2010