Overlooking Evolution: A Systematic Analysis of Cancer Relapse and Therapeutic Resistance Research
A partir d'une analyse de 6 228 articles dont le sujet était la résistance thérapeutique ou la récidive dans les cancers, cette étude évalue la fréquence des concepts relevant de la théorie de l'évolution dans ces travaux
Cancer therapy selects for cancer cells resistant to treatment, a process that is fundamentally evolutionary. To what extent, however, is the evolutionary perspective employed in research on therapeutic resistance and relapse? We analyzed 6,228 papers on therapeutic resistance and/or relapse in cancers and found that the use of evolution terms in abstracts has remained at about 1% since the 1980s. However, detailed coding of 22 recent papers revealed a higher proportion of papers using evolutionary methods or evolutionary theory, although this number is still less than 10%. Despite the fact that relapse and therapeutic resistance is essentially an evolutionary process, it appears that this framework has not permeated research. This represents an unrealized opportunity for advances in research on therapeutic resistance.
PLoS ONE , article en libre accès, 2010