TET2, a tumor suppressor in hematological disorders
Cet article passe en revue les travaux récents sur le rôle du suppresseur de tumeurs TET2 dans les hémopathies malignes
The TET family of proteins has been described a few years ago. Only recently, their roles in DNA modification, through the oxydation of methyl-cytosine, and in normal and malignant development, through the description of TET2 as a tumor suppressor have been documented. The conjunction of these findings has prompted large efforts to understand the biology of these novel entities. Here, we summarize the recent results implicating TET2 in hematological malignancies suggesting that further studies are required to fully understand the role of DNA methylation alterations during transformation.
http://www.sciencedirect.com/science/article/pii/S0304419X11000813