Magnetic Resonance Metabolic Imaging of Glioma
Ces deux études décrivent des méthodes d'imagerie par résonance magnétique, ex vivo et in vivo, permettant de détecter la présence du 2-hydroxyglutarate, un métabolite produit dans les cellules gliales présentant une mutation du gène IDH1
2-Hydroxyglutarate (2-HG) is a potential oncometabolite involved in gliomagenesis that has been identified as an aberrant product of isocitrate dehydrogenase (IDH)–mutated glial tumors. Recent genomics studies have shown that heterozygous mutation of IDH genes 1 and 2, present in up to 86% of grade II gliomas, is associated with a favorable outcome. Two reports in this issue describe both ex vivo and in vivo methods that could noninvasively detect the presence of 2-HG in glioma patients. This approach could have valuable implications for diagnosis, prognosis, and stratification of brain tumors, as well as for monitoring of treatment in glioma patients.
Science Translational Medicine , commentaire, 2012