Are snoRNAs and snoRNA host genes new players in cancer?
Cet article passe en revue les travaux récents sur le rôle de petits ARNs nucléolaires non codants dans l'oncogenèse
Small nucleolar RNAs (snoRNAs) have long been considered important but unglamorous elements in the production of the protein synthesis machinery of the cell. Recently, however, several independent lines of evidence have indicated that these non-coding RNAs might have crucial roles in controlling cell behaviour, and snoRNA dysfunction could consequently contribute to oncogenesis in previously unsuspected ways.