Prostaglandin E2 promotes intestinal tumor growth via DNA methylation
Menée in vitro et in vivo, cette étude établit un lien entre un processus inflammatoire, associé à une tumorigenèse du côlon, et la méthylation de l'ADN en montrant que la prostaglandine E2 réduit au silence certains gènes suppresseurs de tumeurs
Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms underlying DNA methylation alterations in cancer remain unclear. Here we show that prostaglandin E2 (PGE2) silences certain tumor-suppressor and DNA-repair genes through DNA methylation to promote tumor growth. These findings uncover a previously unrecognized role for PGE2 in the promotion of tumor progression.
Nature Medicine 2012