The fundamental role of the p53 pathway in tumor metabolism and its implication in tumor therapy
Cet article passe en revue les travaux récents sur le rôle du gène p53, un suppresseur de tumeurs, dans le métabolisme tumoral
It is well established that the altered metabolism exhibited by cancer cell, including high rates of glycolysis, lactate production, and biosynthesis of lipids, nucleotides, and other macromolecules, which may occur either as a consequence or as a cause of tumorigenesis, plays an essential role in cancer progression. Recently, the tumor suppressor p53 was found to play a central role in this process. Here, we review the role of p53 in modulating tumor metabolism. Specifically, we focus on the functions of p53 in regulating of aerobic glycolysis, oxidative phosphorylation, the pentose phosphate pathway, fatty acid synthesis and oxidation, glutamine metabolism, and discuss the therapeutic strategy whereby p53 helps to prevent malignant progression.