Individualization of cancer treatment from radiotherapy perspective
Cet article fait le point sur le rôle des biomarqueurs prédictifs de la réponse à une radiothérapie et présente l'état des connaissances sur les biomarqueurs associés aux traitements individualisés combinant rayonnements ionisants et anticorps monoclonaux anti EGFR
Radiotherapy is today used in about 50% of all cancer patients, often in multidisciplinary approaches. With major advance in radiotherapy techniques, increasing knowledge on tumor genetics and biology and the continuous introduction of specifically targeted drugs into combined radio-oncological treatment schedules, individualization of radiotherapy is of high priority to further improve treatment outcomes, i.e. to increase long-term tumor cure and/ or to reduce chronic treatment toxicity. This review gives an overview on the importance of predictive biomarkers for the field of radiation oncology. The current status of knowledge on potential biomarkers of tumor hypoxia, tumor cell metabolism, DNA repair, cancer stem cells and biomarkers for combining radiotherapy with inhibition of the epidermal growth factor receptor using monoclonal antibodies is described.
Molecular Oncology , résumé, 2011