Good neighbours in the tumour stroma reduce oxidative stress
Menée in vitro, cette étude met en évidence le rôle joué par la cystine, produite par des cellules de l'environnement stromal, dans la survie de cellules leucémiques soumises à l'agression de molécules cytotoxiques
Tumour cells undergo oncogene-regulated metabolic reprogramming that maximizes survival and growth. However, little is known about metabolic interactions between tumour cells and their non-malignant neighbours in the stroma. Bone-marrow-derived stromal cells are now shown to provide cysteine, an essential nutrient that enables leukaemia cells to resist oxidative stress.