mTORC1: Turning Off Is Just as Important as Turning On
Menées in vitro, ces deux études mettent en évidence des mécanismes par lesquels le complexe suppresseur de tumeurs TSC1-TSC2 régule la désactivation de mTORC1
mTORC1 is activated primarily on the lysosome. Menon et al. and Demetriades et al. show that mTORC1 deactivation on the lysosome is determined by recruitment of its negative regulator, the tumor suppressor complex TSC1-TSC2. These reports highlight the importance of subcellular localization in the regulation of mTORC1.
Cell 2014