Is Adjuvant Chemotherapy Useful for Women With Luminal A Breast Cancer?
Cet article analyse la controverse sur l'intérêt d'une chimiothérapie adjuvante pour les patientes atteintes d'un cancer du sein de type luminal A
Cytotoxic chemotherapy is, on average, beneficial in delaying relapse and prolonging survival for women with early breast cancer. Thus, there is a motivation to prescribe it freely to all or nearly all such women. Guidelines from the 2000 National Institutes of Health Consensus Development Conference stated that “because adjuvant polychemotherapy improves survival, it should be recommended to the majority of women with localized breast cancer regardless of lymph node, menopausal, or hormone receptor status”and that “at the present time, there are no convincing data to support the use of any known biologic factor in selecting a specific adjuvant chemotherapy regimen in breast cancer.” (...)