Central Adiposity and Prostate Cancer in a Black Population
Menée à la Barbade, cette étude (963 cas et 941 témoins) évalue l'association entre l'adiposité centrale et le risque de cancer de la prostate dans une population noire
Background: The relationship between central adiposity and prostate cancer remains unclear. Methods: This report includes 963 newly diagnosed cases of histologically-confirmed prostate cancer and 941 randomly selected controls ascertained from the population-based Prostate Cancer in a Black Population study conducted between July, 2002 and January, 2011 in Barbados, West Indies. Trained nurse-interviewers obtained data on height, weight, waist and hip circumferences, family and medical history, and lifestyle factors. Odds ratios (OR) and 95% confidence intervals (CI) were used to assess associations between anthropometric measures and prostate cancer. Results: A two-fold increased risk of prostate cancer was found among men in the highest quartile of waist-hip ratio compared to those in the lowest quartile (OR=2.11, 95% CI (1.54, 2.88)). Similarly, men with the largest waist circumferences had an OR of 1.84 (95% CI (1.19, 2.85)) compared to those with the smallest waist sizes. Neither height nor BMI were associated with prostate cancer in this population. Conclusions: These results suggest that measures of central rather than global adiposity may be more predictive of prostate cancer, especially in westernized African populations, where patterns of visceral fat distribution are different than other groups. Impact: The findings highlight the need to further elucidate the mechanisms underlying the relationship between central adiposity and prostate cancer in populations of predominantly African descent.