PALB2 Mutations and Breast-Cancer Risk
Menée auprès de 362 femmes issues de 154 familles présentant des mutations du gène PALB2, cette étude analyse l'association entre ces mutations et le risque de cancer du sein
The response to and repair of DNA damage are central to our understanding of the causes of breast cancer. DNA damage results from environmental exposure to genotoxic agents, lifestyle factors, and cellular metabolism. Among the most lethal forms of DNA damage are double-strand breaks. A failure to accurately repair double-strand breaks has catastrophic consequences for the cell, including aneuploidy and genomic instability. Double-strand breaks may be repaired by homologous recombination or by the error-prone process of nonhomologous end joining. Homologous recombination is an important factor in the susceptibility to breast cancer, because BRCA1 is directly involved in the repair of . . .