Prostate stem cell antigen polymorphisms and susceptibility to gastric cancer: a systematic review and meta-analysis
A partir d'une revue systématique de la littérature (9 études, 16 806 cas et 13 982 témoins), cette méta-analyse évalue l'association entre des polymorphismes du gène PSCA et le risque de cancer de l'estomac
Background:Many studies have reported that prostate stem cell antigen (PSCA) polymorphisms (rs2294008 and/or 2976392) are significantly associated with gastric cancer (GC) risk, although the published results are inconsistent. We performed a systematic review and meta-analysis for relevant literatures to quantitatively evaluate the relationship between PSCA polymorphisms and GC susceptibility. Methods:Extensive searches were conducted in three databases up to November 1, 2011. Odd ratios and 95% confidence intervals were used to assess the strength of the associations. The data were further stratified by ethnicity, histopathology, subsite and study design. All of the associations were evaluated with dominant model and recessive model respectively. Heterogeneity and publication bias were also assessed by Q test, I2 and funnel plot, accordingly. Results:Nine articles including 11 case-control datasets were included, with 10746 GC cases and 9158 controls for rs2294008 and 6060 cases and 4824 controls for rs2976392. The results showed that risk allele carriers were significantly associated with GC risk compared with non-risk allele homozygotes. In stratification analyses, these associations remained significant for majority of subgroups except for Caucasians and non-cardia tumor in dominant model, and cardia tumor in both dominant and recessive model. Random model was used when heterogeneity among was detected. No publication bias was observed. Conclusions:The two loci of PSCA (rs2294008 and rs2976392) both were significantly associated with GC susceptibility, and in linkage disequilibrium. Impact:More prospective studies on PSCA polymorphisms at multicentres with sufficient sample size and less heterogeneity will be needed for further validations.