ALK and MYCN: When Two Oncogenes Are Better than One
Menée sur un modèle animal (poisson zèbre) de neuroblastome, cette étude met en évidence le rôle d'une activation du gène ALK, associée à une amplification de MYCN, dans la pathogenèse de ce cancer
Mutations of ALK are frequently observed in MYCN-amplified neuroblastomas and correlate with poor clinical outcome, but how these oncogenes cooperate in neuroblastoma development remains unclear. In this issue of Cancer Cell, Zhu et al. describe a mechanism by which ALK and MYCN synergistically induce neuroblastoma in the zebrafish model system.
Cancer cell , commentaire en libre accès, 2011