Metformin and Pancreatic Cancer: A Clue Requiring Investigation
Menée sur 302 patients atteints d'un diabète et d'un cancer du pancréas, cette étude rétrospective évalue l'association entre la prise de metformine et la survie globale
Laboratory models show antineoplastic activity of metformin under certain conditions, and pharmacoepidemiologic studies have reported reduced cancer burden among diabetics taking metformin. Therefore, the hypothesis that metformin has antineoplastic activity is receiving increasing attention. However, gaps in knowledge must be addressed before metformin can be “repurposed” for oncologic indications. Clin Cancer Res; 18(10); 1–3. ©2012 AACR.
Clinical Cancer Research , commentaire, 2012