• Biologie

  • Oncogènes et suppresseurs de tumeurs

mTOR Signaling in Growth Control and Disease

Cet article passe en revue les travaux récents sur le rôle de la voie de signalisation mTOR dans les maladies humaines, dont le cancer, et le vieillissement

The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis. The pathway regulates many major cellular processes and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration. Here, we review recent advances in our understanding of the mTOR pathway and its role in health, disease, and aging. We further discuss pharmacological approaches to treat human pathologies linked to mTOR deregulation.

Cell 2012

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