Effects of exercise training on exercise capacity in patients with non-small cell lung cancer receiving targeted therapy
Menée sur 24 patients atteints d'un cancer du poumon non à petites cellules et recevant une thérapie ciblée, cette étude évalue l'intérêt d'un programme d'exercices d'aérobic de haute intensité, réalisé sur une période de 8 semaines, pour améliorer la capacité respiratoire et la qualité de vie des patients
Purpose Peak oxygen consumption (VO 2peak ) is an important predictive factor for long-term prognosis in patients with non-small cell lung cancer (NSCLC). The purpose of this study was to investigate whether 8 weeks of exercise training improves exercise capacity, as assessed by VO 2peak , and other related factors in patients with NSCLC receiving targeted therapy. Methods A total of 24 participants with adenocarcinoma were randomly assigned to either the control group ( n = 11) or the exercise group ( n = 13). Subjects in the exercise group participated in individualized, high-intensity aerobic interval training of exercise. The outcome measures assessed at baseline and after 8 weeks were as follows: VO 2peak and the percentage of predicted VO 2peak (%predVO 2peak ), muscle strength and endurance of the right quadriceps, muscle oxygenation during exercise, insulin resistance as calculated by the homeostasis model, high-sensitivity C-reactive protein, and quality of life (QoL) questionnaire inventory. Results No exercise-related adverse events were reported. After exercise training, VO 2peak and %predVO 2peak increased by 1.6 mL kg −1 min −1 and 5.3% ( p < 0.005), respectively; these changes were associated with improvements in circulatory, respiratory, and muscular functions at peak exercise (all p = 0.001). The exercise group also had less dyspnea ( p = 0.01) and favorably lower fatigue ( p = 0.05) than baseline. Conclusions Patients with NSCLC receiving targeted therapy have quite a low exercise capacity, even with a relatively high QoL. Exercise training appears to improve exercise capacity and alleviate some cancer-related symptoms.