CALming Down T Cell Acute Leukemia
Menée à l'aide d'un modèle murin, cette étude suggère que l'inhibition conjointe des isoformes gamma et delta de PI3K est une stratégie intéressante pour le traitement d'une leucémie aiguë lymphoblastique T
Signaling from class I phosphoinositide 3-kinase (PI3K) is often deregulated in leukemia and lymphoma, but which isoforms are involved in T cell acute lymphoblastic leukemia (T-ALL) was not known. In this issue of Cancer Cell, Subramaniam et al. show that T-ALL can be tamed by inhibiting ³ and ´ PI3K isoforms.
Cancer cell , commentaire, 2011