The Pill's gestation: from birth control to cancer prevention
Menée à partir des données de 36 études épidémiologiques portant sur 27 276 patientes atteintes d'un cancer de l'endomètre et 115 743 témoins, cette méta-analyse évalue l'effet protecteur des contraceptifs oraux
Nearly 65 years after Carl Djerassi first produced norethindrone, a synthetic progesterone, from yams in Mexico City, discussions about the risks and benefits of the oral contraceptive pill continue. Oral contraceptives were initially approved by the US Food and Drug Administration (FDA) in 1957 for the treatment of severe menstrual disorders and infertility and then for birth control in 1960. Oral contraceptives are now prescribed widely for several other indications, ranging from acne to endometriosis,1 some of which are FDA approved for women who have also chosen to use oral contraceptives for birth control (figure).
The Lancet Oncology 2015