Association between Colorectal Cancer Susceptibility Loci and Survival Time Following Diagnosis with Colorectal Cancer
Menée sur 2 611 patients atteints d'un cancer colorectal, cette étude évalue l'association entre 16 polymorphismes à simple nucléotide de lignée germinale et la survie des patients
Genome-wide association studies have identified 16 germline single nucleotide polymorphisms (SNPs) that are associated with colorectal cancer (CRC) incidence. We examined the relationship between these SNPs and survival of 2611 individuals with CRC, enrolled in 5 cohort studies. We used Cox regression analysis to associate SNPs with overall and CRC-specific survival times. The minor allele in rs4939827 (SMAD7) was associated with reduced overall survival (hazard-ratio [HR], 1.16; 95% confidence interval [CI], 1.06–1.27; P=.002] and disease-specific survival (HR, 1.17; 95% CI, 1.05–1.30; P=.005). Other SNPs were not significantly associated with survival. Common germline variations might be prognostic factors for patients with CRC. A variant in SMAD7 could affect progression of CRC.
Gastroenterology , résumé, 2011