Decreased survival among lung cancer patients with co-morbid tuberculosis and diabetes
A partir de données d'un registre médical taïwanais, cette étude évalue la surmortalité associée à un diabète ou une tuberculose chez les patients atteints d'un cancer du poumon (1 111 cas)
BACKGROUND:Comorbid conditions influence the survival of cancer patients. This study evaluated the influence of comorbidity on survival among lung cancer patients.METHODS:The authors evaluated the medical records of 1111 lung cancer patients of a medical center in Taiwan. Days of survival were calculated for each patient and mortality hazard ratios were estimated for associations with demographic status, comorbidity and cancer stage at diagnosis.RESULTS:On average, the survival time was slightly longer among women than among men (838 +/- 689 vs. 749 +/- 654 days, p = 0.050). Survival days increased with age (from 580 +/- 526 [[less than or equal to] 50 years] to 803 +/- 693 [[greater than or equal to] 71 years] days, p = 0.020) and decreased with stage (from 1224 +/- 656 [stage I] to 489 +/- 536 [stage IV] days, p < 0.001). Younger patients were more likely to be diagnosed with lung cancer at a late stage. Compared with lung cancer patients without tuberculosis, those with tuberculosis had a significantly shorter average survival duration (584 vs. 791 days, p = 0.002) and a higher mortality hazard ratio (1.30, 95% CI: 1.03 - 1.65). A similar trend was observed in lung cancer patients with diabetes.CONCLUSIONS:Lung cancer patients with comorbid tuberculosis or diabetes are at an elevated risk of mortality. These patients deserve greater attention while undergoing cancer treatment. Key words: Lung cancer, comorbidity, diabetes, survival, tuberculosis.