Network Medicine Strikes a Blow against Breast Cancer
Menée sur des lignées cellulaires et à l'aide de xénogreffes, cette étude montre notamment qu'un inhibiteur d'EGFR sensibilise des cellules de cancer du sein triplement négatif à un agent cytotoxique si les deux molécules sont administrées en séquence et non simultanément
Drug development for complex diseases is shifting from targeting individual proteins or genes to systems-based attacks targeting dynamic network states. Lee et al. now reveal how the progressive rewiring of a signaling network over time following EGF receptor inhibition leaves triple-negative breast tumors vulnerable to a second, later hit with DNA-damaging drugs, demonstrating that time- and order-dependent drug combinations can be more efficacious in killing cancer cells.
Cell , commentaire, 2011