A review of expression profiling of circulating microRNAs in men with prostate cancer
Cet article passe en revue les travaux récents sur l'intérêt de la mesure des niveaux sériques de micro-ARNs pour le diagnostic et le pronostic d'un cancer de la prostate
What's known on the subject? and What does the study add? MicroRNAs are small, single-stranded RNA molecules that are stable in the circulation. These molecules have been identified as potential circulating biomarkers for several malignancies. In this review we provide a comprehensive overview of the publications that have identified dysregulated microRNAs in the circulation of men with prostate cancer. * •MicroRNAs (miRNAs) are small non-coding RNAs that are involved in gene regulation and expression. These molecules have been implicated in the pathogenesis of several malignancies. * •MiRNAs have the potential to be both a tissue- and blood-based biomarker for cancer diagnosis, classification, prognosis and response to treatment. * •The levels of dysregulated miRNAs in the circulation of individuals make miRNAs an ideal biomarker for the detection of prostate cancer. * •The present study provides a comprehensive review of the expression profiling of miRNAs in the circulation of men with prostate cancer. * •Further research is necessary to identify if circulating miRNAs have the potential to be a biomarker for prostate cancer in clinical practice.
BJU International , résumé, 2011