Comparing participation rates between immunochemical and guaiac faecal occult blood tests : A systematic review and meta-analysis
A partir d'une revue systématique de la littérature publiée entre 2000 et 2011 (7 essais), cette méta-analyse compare les taux de participation à des programmes de dépistage du cancer colorectal proposant un test immunochimique ou un test au gaïac pour la recherche de sang occulte dans les selles
Background Biennial screening with faecal occult blood tests (FOBt) has been found to reduce colorectal cancer mortality. Faecal immunochemical tests (FIT) are superior to guaiac FOBt (G-FOBt) due to their improved sensitivity and specificity. However the effectiveness of a screening programme depends highly on participation rates. The aim of this study was to review studies comparing G-FOBt and FIT, in terms of participation rates. Methods We searched PubMed and the Cochrane Library (2000-September 2011) to identify randomised control trials comparing G-FOBt with FIT participation rates. One author screened the titles and abstracts, and performed data extraction which was then checked by the other authors. Risk of bias in the included studies was also assessed. Results Seven studies met the eligibility criteria and were entered into a meta-analysis. Participation rates were significantly higher for individuals offered FIT compared to those offered a G-FOBt (RR 1.21; 95% CI 1.09-1.33). Potential factors that could have influenced participation were discussed. Conclusions Colorectal cancer screening programmes currently using G-FOBt could improve participation rates by converting to FIT. More research examining the acceptability of FIT, from a patient perspective, is warranted.
Preventive Medicine , résumé, 2011