Circulating DNA: Diagnostic Tool and Predictive Marker for Overall Survival of NSCLC Patients
Menée sur 104 patients atteints d'un cancer du poumon non à petites cellules nouvellement diagnostiqué et sur 205 témoins, cette étude évalue l'association entre les niveaux plasmatiques de l'ADN tumoral circulant et la survie globale des patients
Purpose : The purpose of our study was to determine whether the amounts of circulating DNA (cDNA) could discriminate between NSCLC patients and healthy individuals and assess its value as a prognostic marker of this disease.
Methods : We conducted a study of 309 individuals and the cDNA levels were assessed through real-time PCR methodology.
Results : We found increased cDNA levels in NSCLC patients compared to control individuals. We also found a decreased overall survival time in patients presenting high cDNA levels, when compared to lower cDNA concentrations.
Conclusions : Quantification of cDNA may be a good tool for NSCLC detection with potential for clinical applicability.
PLoS ONE , article en libre accès, 2011